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KMID : 1103920080140010102
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Korean Journal of Hepatology
2008 Volume.14 No. 1 p.102 ~ p.107
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A case of ticlopidine induced acute cholestatic hepatitis and pure red cell aplasia
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Lee Ji-Yeon
Park Eun-Bum
Ahn Jae-Hong
Suh Sang-Jun
Jung Young-Kul
Kim Ji-Hoon
Shin Bong-Kyung
Yang Jin-Hyuk
Yeon Jong-Eun
Byun Kwan-Soo
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Abstract
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Ticlopidine inhibits platelet aggregation and provides beneficial secondary prevention of cerebrovascular and coronary artery disease. Frequently reported adverse effects of ticlopidine include diarrhea, nausea, and rash. However, to our knowledge, there are only a few published reports of the simultaneous occurrence of cholestatic hepatitis and pure red cell aplasia. Here we report a patient with simultaneous severe cholestatic hepatitis and pure red cell aplasia associated with ticlopidine. Although these adverse effects are rare, periodic hematological and liver function tests are recommended after starting ticlopidine. (Korean J Hepatol 2008; 14:102-107)
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KEYWORD
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Ticlopidine, Pure red cell aplasia, Hepatitis, Drug-Induced, Adverse effect
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